Wednesday, September 26, 2007

Big favor? Don't get shot up with weird stuff

…Natasha Singer (NYT, Sept 2007) talks about the latest get-thin-quick scheme, lipodissolve.

….This actually started in St Louis, not some celebrity-infested coastal city.

…This amounts to sticking long needles pretty far in the cottage-cheesy areas and injecting a drug that supposedly breaks down cells in the fatty layer.

…Then where do they go? That is the problem. The FDA has not approved this.

…But that isn’t stopping the good matrons of the Midwest—they can’t wait to get this.
You know those fig. commercials—fig. does this!

…The board of medicine in Kansas tried to ban the drug after complaints, but a judge stayed the order.

…The docs argue that each drug in the compound is approved and it’s OK to smash them together.

…Cosmetic medicine is frighteningly unregulated, one doc said.

…But, don’t forget, each body part requires $2,000 in treatments. “Fig”ure that!

…One doctor was considering offering it, had himself injected (gosh, HA wishes more would road-test these treatments) and half an hour later, saw his flank turn black and feel like it had been stung by 50 bees, according to this account.

…Another male doc in the group also tried it and looked six months pregnant.

…Come on, readers, when a drug is supposed to go body-wide, what do they do? They inject it!



Dr Barry Lycka said...

There are 24 studies in the medical literature favorable to lipodissolve
Yagima Odo ME, Cucé LC, Odo LM, Natrielli A.
Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects. Dermatol Surg. 2007 Feb;33(2):178-88; discussion 188-9

Bechara FG, Sand M, Hoffmann K, Sand D, Altmeyer P, Stucker M
Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study.
J Cutan Pathol. 2007 Jul;34(7):552-7.

Salles AG, Valler CS, Ferreira MC. Histologic response to injected phosphatidylcholine in fat tissue: experimental study in a new rabbit model.
Aesthetic Plast Surg. 2006 Jul-Aug;30(4):479-84; discussion 485

Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg. 2006 Apr;32(4):465-80

Bechara FG, Sand M, Sand D, Rotterdam S, Stücker M, Altmeyer P, Hoffmann K. Lipolysis of lipomas in patients with familial multiple lipomatosis: an ultrasonography-controlled trial J Cutan Med Surg. 2006 Jul-Aug;10(4):155-9.

Rittes PG, Rittes JC, Carriel Amary MF. Injection of phosphatidylcholine in fat tissue: experimental study of local action in rabbits. Aesthetic Plast Surg. 2006 Jul-Aug;30(4):474-8.

Rose PT, Morgan M. Histological changes associated with mesotherapy for fat dissolution. J Cosmet Laser Ther. 2005 Mar;7(1):17-9

Bechara FG, Sand M, Altmeyer P, Hoffmann K. Intralesional lipolysis with phosphatidylcholine for the treatment of lipomas: pilot study. Arch Dermatol. 2006 Aug;142(8):1069-70; author reply 1070

Kopera D, Binder B, Toplak H, Kerl H, Cerroni L. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol. 2006 Aug;28(4):331-3

Hexsel D, Serra M, Mazzuco R, Dal'Forno T, Zechmeister D. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol. 2003 Oct;2(5):511-8

Kopera D, Binder B, Toplak H. Intralesional lipolysis with phosphatidylcholine for the treatment of lipomas: pilot study. Arch Dermatol. 2006 Mar;142(3):395-6

Rittes PG, Rittes JC, Carriel Amary MF. Injection of phosphatidylcholine in fat tissue: experimental study of local action in rabbits. Aesthetic Plast Surg. 2006 Jul-Aug;30(4):474-8

Rotunda AM, Ablon G, Kolodney MS. Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol. 2005 Dec;53(6):973-8. Epub 2005 Oct 19

Hasengschwandtner, F Injection Lipolysis for Effective Reduction of Localized Fat in Place of minor surgical Lipoplasty Aesthetic Surgery Journal, 2006 125-130.

Heinrich Karl G. Efficacy of Injections of Phosphotidylcholine Onto Fat Deposits: A Non-Surgical Alternative to Liposuction in Body-Contouring
Presented at the Coinvention Operative Dertmatologie, Frankfurt 28 -31., 10, 2005

Hasengschwandtner, F Phosphatidylcholine treatment to induce liolysis J of Cosmetic Dermatology, 2005, 4, 308-313.

Duncan, D. Hasengschwandtner, F Lipodissolve for subcutaneous Far Reduction and Skinx Retyraction Aesthetic Surgery J, 2005, 530-543.

Hasengschwandtner F. Treatment with Phosphatidylcoline in reference to Lipodissolve. (June 2004).

Ablon, G. Rotuns A M Treatment of Lower Eyelid Fat Pads Using Phosphatidylcholine: Clinical Trial and Review. Dermatologic Surgery, 30 Issue 3: 422: March 2004

Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatol Surg. 2004 Jul;30(7):1001-8

Rittes PG The Use of Phosphatidylcholine for Correction of Localized Fat Deposits.: Am Soc for Aesth Plastic Surg 2003: 27; 315-318

Hasengschwandtner F Examination of blood values after subcutaneous administration of PC. EACS 2005, Austria

Doris Hexsel, MD Phosphatidylcholine in the treatment of Localized Fat. Professor of Dermatology, Plinio, Brazil. Ref: October 2003.

Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg. 2001 Apr;27(4):391-2

Star Lawrence said...

Thanks for sharing these. I take it you offer this service.

Healthy Focus said...

Hello....just wanted to offer a small comment on this. Phosphatidylcholine, one of the components in these injections, is not a drug. It is a dietary supplement. Actually, it is derived from Lecithin, which is sold in health food stores to be sprinkled on top of yogurt, salad, etc. I have taken Phosphatidylcholine in softgel supplement form internally for about ten years, as it is known to be one of the most inexpensive yet potent fighters of bad cholesterol. And, it works. My doctor is constantly amazed at my triglyceride levels (38) given that my dad's family is a bunch of walking heart attack time bombs. :)

I came across this mesotherapy stuff while researching a way to get rid of my dog's fatty lipomas in a non-surgical way. He has already had 3 operations, and they are expensive and painful for him. I was contemplating giving him my PC softgels, but I feel that internal ingestion will not solve his particular problem, as fatty lipomas are encapsulated fat deposits. I began thinking about an injection, and lo and behold, came across an article referring to just such a thing for lipomas. I also saw all the other offerings for the plastic surgery crowd. Knowing what I know about chemistry and supplements, I actually have to say that as long as doctors and pharmaceutical companies are not allowed to bastardize the two components used in these injections AT ALL, then this sounds like a safe and possibly very effective way of handling stubborn localized fat deposits. Keep in mind, I hate doctors, big-pharma, plastic surgery and any other quick method of dealing with beauty issues that should be addressed through diet and exercise first. However, I believe that this method is one of the few safe ones proposed by the quacks in the industry (I am sure they stumbled over it and did not figure it out on their own). I am sure they will find a way to mess it up though. Already, the cost is ridiculous for something that you could potentially gather the ingredients and perform yourself for about $5 an injection (do NOT do this, due to the lack of knowledge on dosage and antiseptic procedures).

Anyway, just my two cents. My curiosity is aroused, and I will be discussing this with my vet for the doggie treatment. Apparently, a compounding pharmacy can put together liquid PC for injections for you. Go bag it big pharma!

Star Lawrence said...

FYI--Fig, the company pushing this, went er...belly up on Dec
12. HA is just sayin'.

Anonymous said...

I myself have used Sodium Deoxycholate via injection on 2 very large lipoma I have in my body..I knew about this method awhile back, and instead of going to some "spa" to get raped on the price, I know how can get the stuff for, I have been hearing when used sparingly, it has shown evidence to cause colon cancer, but strangely, when used vigorously, it does not. guess since ive used it pretty vigorously I shouldnt have a problem there.

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